Regeneron Hiring Postdoctoral Fellow- Apply Online!
Regeneron is currently seeking Postdoctoral Fellows with expertise in Immunology, Oncology, or Cell Biology to join their cutting-edge research initiatives. This role offers a unique opportunity for recent PhD graduates and early-career scientists to collaborate with top-tier researchers, access advanced resources, and contribute to groundbreaking research in the pharmaceutical industry.
Job Title: Postdoctoral Fellow- Oncolytic Viruses
Company Name: Regeneron
Location: Tarrytown, New York, United States of America
Essential Qualification: Ph.D. in immunology, oncology, or cell biology.
Experience: Hands-on experience in techniques such as flow cytometry, cell culture, and mouse experimentation. Expertise in T-cell biology is highly desired.
Salary Range (annually): $69,500.00 – $113,500.00
Job Description: The Infectious Disease team is seeking to fill a postdoc position focused on assessing anti-tumor immune responses to oncolytic virus therapy. The successful applicant will work closely with infectious disease and immuno-oncology teams while pursuing an independent research project. We are looking for a candidate with a background in anti-tumor immunology and a proven record of accomplishments in the field.
Roles and Responsibilities:
- Independently craft, plan, and perform/supervise complex anti-tumor efficacy studies in mice
- Animal experimentation, Dissection of tumors/organs for immune cell isolation and subsequent analysis.
- Design advanced flow cytometry (FACS) panels and perform/supervise FACS analysis on immune cells isolated from tumors and tissues.
- Analyze data using biological and statistical software such as Flowjo, Prism, Excel, etc.
- Collaborate closely with cross-functional teams across the company.
- Compile results across experiments and programs and present them to multi-disciplinary teams, including translational teams, and senior management.
- Document experimental procedures and results in a well-organized fashion; generate experimental reports and write manuscripts for journal submission.
- Participate in post-doctoral program activities (e.g., weekly meetings and annual research conference)
- Continuously follow the current relevant literature, attend scientific meetings, and maintain expertise in the field of Immunology and Immuno-Oncology.
Required Skills:
- Are a creative thinker with a track record of productivity
- Enjoy driving your ideas forward and leading your research project
- Have outstanding scientific skills, including critical and analytical thinking
- Have strong communication and presentation skills
- Like to actively participate and effectively collaborate in exciting cross-functional projects that involve multiple teams
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Possible Interview Questions and Answers:
1. Question: Can you describe your experience with designing and conducting complex anti-tumor efficacy studies in mice?
Answer: In my previous research, I have designed and executed several complex anti-tumor efficacy studies in mouse models. These studies involved careful planning, including selecting appropriate mouse models, treatment protocols, and outcome measures. I ensured ethical and rigorous experimental design throughout, including randomization and blinding when necessary. These experiences have equipped me with the skills to independently plan and execute similar studies for this position.
2. Question: How do you approach the design of advanced flow cytometry (FACS) panels for immune cell analysis? Can you provide an example of a complex FACS panel you have designed?
Answer: Designing advanced FACS panels is critical for in-depth immune cell analysis. I approach this by first identifying the specific immune cell subsets of interest and the markers that distinguish them. Then, I consider factors like fluorochrome compatibility, compensation, and gating strategies. For instance, in a recent project, I designed a 14-color FACS panel to characterize myeloid-derived suppressor cells (MDSCs) within tumors. This panel included markers for various MDSC subsets, activation markers, and lineage markers to ensure comprehensive analysis.
3. Question: How do you ensure the robustness and reliability of your data analysis, particularly when working with complex datasets?
Answer: Robust data analysis is essential in immunology research. I employ a systematic approach by first ensuring data quality through proper instrument calibration and controls during FACS acquisition. I then use standardized gating strategies and established data preprocessing steps to reduce variability. To analyze complex datasets, I often use software such as Flowjo and Prism, which allow for rigorous statistical analysis and visualization. Additionally, I follow best practices in data documentation to maintain transparency and reproducibility.
4. Question: Can you describe a challenging experience you’ve had while collaborating with cross-functional teams, and how did you handle it?
Answer: Collaboration is a key aspect of research, and challenges can arise. In one project, I encountered a situation where the goals of our immunology team conflicted with those of the virology team regarding treatment protocols. To address this, I initiated open and constructive communication with both teams to understand their perspectives. We then worked together to find a compromise that satisfied both sides while ensuring the scientific integrity of the study. This experience reinforced the importance of effective communication and teamwork.
5. Question: How do you stay updated with the latest developments in immunology and immuno-oncology, and how do you apply this knowledge to your research?
Answer: Staying updated in the rapidly evolving field of immunology and immuno-oncology is crucial. I regularly read scientific journals, attend conferences, and participate in webinars to keep abreast of the latest research findings and emerging technologies. Moreover, I actively engage in discussions with colleagues and collaborators to exchange insights and ideas. I believe in applying this knowledge by incorporating cutting-edge techniques and concepts into my research to ensure its relevance and innovation.
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