Biochemistry/Cell Biology We are hiring multiple highly motivated postdoctoral fellows to perform independent research projects as part of a core team of cross-functional scientists and critical problem solvers, passionate about the theme of Emerging Therapeutic Modalities. The positions are for 2-4 years depending on time to complete projects. Successful candidates will have access to Amgen’s innovative technologies and innovation and be encouraged to make exciting scientific contributions to the field, present at scientific conferences and publish their work. Postdocs will be a part of the broader R&D Postdoc Program that focuses on training the next generation of industry scientists. An overwhelming majority of our postdocs go on to advance their careers in industry at leading pharma and biotech companies, including many at Amgen.
Job Title: POSTDOCTORAL FELLOW – EMERGING THERAPEUTIC MODALITIES
Location: US, CA,Thousand Oaks
Biochemistry/Cell Biology Biochemistry/Cell Biology We are looking for dedicated, self-motivated individuals passionate about science and making high impact discoveries to work on Emerging Therapeutic Modalities. A major focus will be in the exciting area of Proximity Biology, including Targeted Protein Degradation, E3 ubiquitin ligases, PROTACs and molecular glues. Design principles to overcome challenges in Targeting, Develop-ability and ADME will be elucidated for these novel modalities. New postdoctoral fellows will take a multi-disciplinary approach combining chemical biology, molecular biology, biochemistry, cell biology, pharmacology, and analytical chemistry to carry out these studies.
Please see representative publications:
Cell. 2015 160, 715-28.
Cell. 152, 1051-1064.
Molecular Cell. S1097-2765(20)30466-4.
Molecular Cell. 77(6):1206-1221.e7.
Molecular Cell. 69,113-25.
Science Advances. 5(5):eaav4832.
Nature Communications. 11(1):4931
Drug Metab Dispos. DMD-AR-2021-000798
Drug Metab Dispos. 47(10):1097-1099
J Med Chem. 63(12):6407-6422
Analytical Chemistry 93(13):5562-5569
WIN
WHAT WE EXPECT OF YOU
We are all different, yet we all use our unique contributions to serve patients. The Postdoctoral Fellow we seek is a professional with these qualifications.
BASIC QUALIFICATIONS
PhD at the time of appointment
PREFERRED QUALIFICATIONS
- PhD in biochemistry, molecular biology, cell biology, cancer biology, pharmacology, chemistry, or pharmaceutical sciences.
- Broad knowledge of molecular and cellular biology with demonstrated independent research eminence through first author publications in top journals
- Specific expertise and a record of publication in the biology and biochemistry of ubiquitin-proteasome system and/or protein degradation Research experience with biochemical, biophysical, molecular and cellular techniques, including enzyme and cell assay development, characterization of protein modification and turnover, and mechanistic studies of enzymes, including developing drug-target engagement assays
Understanding of mechanistic pharmacokinetic principles including drug absorption, permeability, and key factors in optimizing bioavailability of new chemical entities
Research experience with establishing novel assays to understand the role of drug transporters in both absorption and clearance - Comprehensive knowledge of analytical chemistry with a focus on mass spectroscopy skills for quantitation of proteins and peptides out of biological matricesical matrices
Excellent organizational, interpersonal and communication skills - A passion to explore the unknown and make discoveries that will chart new areas of biology
- THRIVE
WHAT YOU CAN EXPECT OF US
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.
The annual base salary range for this opportunity in the U.S. is $77,626 – $86,250.
In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
- Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentivesAward-winning time-off plans and bi-annual company-wide shutdowns - Flexible work models, including remote work arrangements, where possible
You may visit the Post Doctoral Fellows Career Page for more information and opport - Biochemistry/Cell Biology
